The skull's edges were sealed with clear nail polish because I could not find my Fraycheck. If you plan on using or laundering your item, you would not want to do what I did, but since I knew that this piece would live on the wall, clear nail polish worked just fine. You could also turn the edges, but I find that tedious, and just felt it was an unnecessary step for this particular project.
I blanket stitched the skull onto the backing fabric, and then blanket stitched the eyes and nose onto the skull before getting down to the REAL stitchin'. I did not have a set design in my mind, just a palette of colors I had chosen. I incorporated some sequins and metallic floss for a bit of sparkle, but I seriously dislike using metallic floss. That stuff is seriously a pain in the ass. I have heard better things about other brands of metallic threads, but I have DMC in my stash, and that shit is annoying to work with. It looks good, though, so it often makes it's way into my work. I just made up the design while stitching.
This guy currently lives on my kitchen wall.